| S2815 |
Lixivaptan (VPA-985) |
Lixivaptan (VPA-985, CRTX 080, WAY VPA 985) is an oral, non-peptide, selective V2 receptor vasopressin antagonist with IC50s of 1.2 nM and 2.3 nM for human V2 receptor and rat V2 receptor, respectively. |
Selective |
human V2 receptor, IC50: 1.2 nM; rat V2 receptor, IC50: 2.3 nM |
| S2593 |
Tolvaptan |
Tolvaptan (OPC-41061) is an orally effective nonpeptide arginine vasopressin V2 receptor antagonist with IC50 of 3 nM, used to treat hyponatremia. |
Selective |
vasopressin receptor 2, IC50: 3 nM |
| S2920 |
Mozavaptan |
Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively. |
Selective |
Vasopressin receptor 2, IC50: 14 nM |
| S2116 |
Conivaptan HCl |
Conivaptan HCl(YM 087) is an orally active, non-peptide, vasopressin V1A and V2 receptor antagonist, used in the treatment of euvolemic and hypervolemic hyponatremia. |
Pan |
|
